【摘要】 目的:探讨妊娠糖尿病前期早期干预及胎儿健康状况的效果评价。方法:筛查的2 379例孕妇中,空腹血糖受损88例,糖耐量受损364例,知情同意后共400例参与项目研究,并随机分为干预组及对照组各200例。对干预组实施早期干预模式,比较两组的糖耐量受损、相关生化指标及妊娠高危及并发症情况。结果:干预组干预后GDM、GIGT持续、持续空腹血糖受损、产后OGTT的发生率均低于对照组,非炎症反应(C反应蛋白)的发生率高于对照组,羊水过多、巨大儿的发生率低于对照组,胎儿生长发育指数干预组良好率高于对照组,以上差异均具有统计学意义(P<0.05)。结论:实施妊娠期糖尿病前期早期干预有利于降低GDM发病率,减少并发症,促进母婴安康。更多还原

【Abstract】 Objective:To explore the effectiveness evaluation of early intervention of pregnant women with gestational diabetes mellitus(GDM) at early stage and the health status of fetuses.Methods:Among 2 379 pregnant women receiving GDM screening,88 pregnant women were found with impaired fasting glucose,364 pregnant women were found with gestational impaired glucose tolerance(GIGT);a total of 400 pregnant women participated in the study after informed consent,then they were randomly divided into intervention group and control group,200 pregnant women in each group.The pregnant women in intervention group received early intervention.GIGT,related biomarkers,and complications in the two groups were compared.Results:The incidences of GDM,GIGT,persistent impaired fasting glucose,postpartum oral glucose tolerance test(OGTT) in intervention group after intervention were significantly lower than those in control group;the incidence of non-inflammatory reaction in intervention group was significantly higher than that in control group;the incidences of polyhydramnios and macrosomia in intervention group were significantly lower than those in control group,the fetal growth and development index in intervention group was significantly higher than that in control group(P<0.05).Conclusion:Early intervention of GDM contributes to reducing the incidence of GDM and complications,and promoting maternal and fetal health.更多还原