【摘要】 目的探讨老年冠心病心绞痛患者血清中hs-CRP的浓度与病情严重程度之间的关系以及瑞舒伐他汀进行干预治疗的价值。方法用免疫透射比浊法分别定量检测健康对照组40例、不稳定型心绞痛患者组45例和稳定型心绞痛患者组40例治疗前的hs-CRP水平。对于血清中hs-CRP增高者,随机对其分成瑞舒伐他汀干预治疗组和常规治疗组。分别在用药后4、8周检测血清hs-CRP水平。结果不稳定型心绞痛患者组治疗前血清hs-CRP水平显著高于稳定型心绞痛患者组及健康对照组(P<0.01);而稳定型心绞痛患者组血清hs-CRP水平与健康对照组比较,差异无统计学意义(P>0.05)。治疗前不稳定型心绞痛患者组、稳定型心绞痛患者组的血清hs-CRP增高(均>3.0 mg/L)的阳性率分别为75.6%和5.0%。瑞舒伐他汀干预治疗组经治疗4～8周较常规治疗组血清hs-CRP水平明显降低(P<0.01)。结论老年冠心病心绞痛患者的冠脉内不稳定病变与血清hs-CRP水平有一定相关,瑞舒伐他汀可以明显降低此类患者的血清hs-CRP水平,有助于对冠状动脉内不稳定病变的治疗,并且安全有效,值得推广。更多还原

【Abstract】 Objective To investigate the relationship between the severity of elderly angina pectoris and serum hs-CRP concentrations,and the value of intervention for Rosuvastatin.Methods By using the immune turbidimetric method,quantitative detection of these patients were pre-treatment serum hs-CRP levels,including the healthy control group of 40 patients,45 patients with unstable angina,stable angina group of 40 patients.For increased serum hs-CRP in patients randomly assigned to Rosuvastatin treatment intervention group and the conventional therapy group.The two groups were detected in patients with serum hs-CRP levels in 4 and 8 weeks after treatment.Results Patients with unstable angina group before treatment serum hs-CRP levels were significantly higher than patients with stable angina group and the healthy control group(P < 0.01);And stable angina in patients with serum hs-CRP levels compared with healthy controls,there was no significant difference(P > 0.05).Before treatment,patients with unstable angina group,patients with stable angina group,increased serum hs-CRP(greater than 3.0 mg/L) of the positive rates were 75.6% and 5.0%.Rosuvastatin intervention group 4-8 weeks after treatment compared with conventional treatment group,serum hs-CRP levels were significantly lower(P < 0.01).Conclusion For elderly angina pectoris,unstable coronary artery disease and serum hs-CRP levels have a correlation.Rosuvastatin can significantly reduce these patients serum hs-CRP levels,contribute to the unstable coronary artery disease treatment.This treatment is safe and effective,should be promoted.更多还原