【摘要】 目的探讨乙型肝炎病毒X蛋白(HBx)、雄激素受体(AR)在肝细胞癌(HCC)中的表达及意义。方法采用SP免疫组化方法检测58例患者乙型肝炎病毒相关原发肝细胞癌组织(HCC)及相应癌旁组织中HBx、AR的表达,并分析其与临床病理特征的关系。结果 HCC和癌旁组织中HBx及AR的表达率为63.8%(37/58)、58.6%(34/58)和20.9%(12/58)、27.6%(16/58),差异有统计学意义(P<0.05)。HBx阳性和HBx阴性的HCC组织中AR的表达率分别为72.3%(27/37)和33.3%(7/21),在HCC组织中HBx表达与AR表达正相关(r=0.4532,P<0.05)。HBx染色的阳性率与AFP水平和Edmondson分级相关;AR染色的阳性率与性别及肿瘤直径相关。结论在HCC组织中HBx蛋白可上调AR的表达,HBx-AR信号传导途径可能促进HBV相关肝细胞癌的发生发展。更多还原

【Abstract】 Objectve To investigate expression of HBx and androgen receptor(AR) in hepatocellular carcinoma(HCC) and its significance.Methods The expressions of the proteins mentioned above in 58 hepatitis B virus(HBV) related HCC tissues and their corresponding non-cancerous adjacent liver tissues were detected by SP immunohistochemistrymethod,and the follow-up informations of the patients were investigated.Results The positive expression of HBx、AR in HHC tissues was 63.8%(37/58)and 58.6%(34/58).It was 20.9%(12/58) and 27.6%(16/58) in non-cancerous adjacent liver tissues.deifferences were signicant(P < 0.05).The positive expression of AR in HHC tissues with HBx-positive and in HHC tissues with HBx-negative was 72.3%(27/37) and 33.3%(7/21),the deifferences were signicant(P < 0.05).There were significnant correlations between the expression of HBx and survivin and p53 in HCC tiusses(r = 0.4532,P < 0.05).The expression rates of HBx was related to Edmondson grade and AFP level,the expression rates of AR was related to gender and tumour size.Conclusion In HBx-postive hepatocellular carcinoma HBx up-regulate expresses of AR suggest HBx with AR signaling pathway involved in HBx-related hepatocarcinogenesis.更多还原