【摘要】 目的观察冻干重组人脑利钠肽(新活素)对顽固性心力衰竭患者的血液动力学影响及临床效果。方法收集顽固性心力衰竭患者98例,监测和比较新活素治疗前后血液动力学参数、生化和临床指标。结果顽固性心力衰竭患者接受新活素治疗后,心率和肺毛细血管楔压显著下降,心脏指数显著升高,呼吸困难、心功能和全身临床状况显著改善,尿量显著增多,血浆脑利钠肽浓度显著下降,未发现与新活素相关的症状性低血压及其他严重不良反应。结论新活素治疗顽固性心力衰竭有着较好的血流动力学效应和临床效果,且安全可行。更多还原

【Abstract】 Objective To observe hemodynamic effects and efficacy of recombinant human brain natriuretic peptide(rhBNP) in the patients with refractory heart failure.Methods Ninty-eight consecutive patients with refractory heart failure were enrolled into this study.The hemodynamic parameters,blood variables and clinical changes between post-and pre-infusion were monitored and compared.Results After rhBNP infusion,pulmonary capillary wedge pressure and heart rate were significantly reduced,cardiac index was increased obviously,Improvement in dyspnea grade,patient’s symptoms and signs,and heart function was significant,the total urine output were enhanced significantly and blood brain natriuretic peptide concentrations were also decreased.There was no symptomatic hypotension or other adverse events during infusion.Conclusions Intravenous injection of rhBNP results in effective hemodynamic improvements and good clinical efficacy,and is also feasible and safe for clinical use in the patients with refractory heart failure.更多还原