【摘要】 目的研究苦瓜Momordica charantia叶的化学成分。方法采用硅胶、Sephadex LH-20等多种柱色谱方法进行分离纯化,通过理化常数和波谱分析鉴定化合物的结构。结果从苦瓜叶95%乙醇提取物中分离得到11个化合物,分别鉴定为(19S,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol(1)、(19R,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol(2)、3β,7β,25-trihydroxycucurbita-5,23-dien-19-al(3)、3β,7β,25-trihydroxycucurbita-5,23-dien-19-al-3-O-β-D-glucopyranoside(4)、苦瓜素Ⅰ(5)、苦瓜素Ⅳ(6)、大豆脑苷Ⅰ(7)、α-菠甾醇(8)、α-香树素乙酸酯(9)、β-谷甾醇(10)和胡萝卜苷(11)。结论化合物1、3、8～11为首次从该植物中分离得到。更多还原

【Abstract】 Objective To study the chemical constituents from the leaves of Momordica charantia.Methods The compounds were isolated and purified by column chromatography on silica gel,ODS,Sephadex LH-20,and preparative HPLC.Their structures were identified by physicochemical properties and spectral data.Results Eleven compounds were isolated from 95% ethanol extract of M.charantia and elucidated as(19S,23E)-5β,19-epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol(1),(19R,23E)-5β,19-epoxy19-methoxycucurbita-6,23-diene-3β,25-diol(2),3β,7β,25-trihydroxycucurbita-5,23-dien-19-al(3),3β,7β,25-trihydroxycucurbita-5,23-dien-19-al-3-O-β-D-glucopyranoside(4),momordicin Ⅰ(5),momordicin Ⅳ(6),soya-cerebroside Ⅰ(7),α-spinasterol(8),α-amyrin acetate(9),β-sitosterol(10),and daucosterol(11),respectively.Conclusion Compounds 1,3,and 8—11 are isolated from M.charantia for the first time.更多还原