【摘要】 目的 对红宝石点阵激光联合氨甲环酸片治疗黄褐斑进行临床疗效观察。方法 激光治疗:采用点阵模式,能量密度2.5～3.5J/cm2,每隔2周治疗1次,2个月为1个疗程;同时口服氨甲环酸片500mg,1次/d,2个月为1个疗程,连续治疗3个疗程;对患者进行黄褐斑皮损面积和严重程度指数(MASI)评分,采用自身治疗前/后对照法进行疗效观察,记录起效时间、复发情况及不良反应等。结果 120例患者经过半年的治疗后,并随访半年至1年,118例患者出现了不同程度的色斑减轻,有效率为65.84%。停止治疗后8例患者出现色斑复发,7例患者在服药期间感觉月经量减少,未发现明显炎症后色素沉着及其他不良反应的发生。结论 红宝石点阵激光联合氨甲环酸片治疗黄褐斑是一种疗效显著,且安全性高的治疗方法。更多还原

【Abstract】 Objective To observe the clinical therapeutic efficacy of ruby dot matrix laser combined with tranexamic acid tablets in the treatment of melasma.Methods Laser treatment:choice dot matrix pattern,with energy density from 2.5mJ/mm2 to 3.5mJ/mm2.Everyone accepted treatment twice one month.One course included 4 times of treatment.Everyone accepted only one course treatment.Tranexamic acid tablets treatment:Everyone was given tranexamic acid tablets 500mg per day,2 months as 1 course.Everyone accepted 3 courses treatment.The severity and the area of melasma was assessed by two dermatologists using the melasma area severity index(MASI).At regular in tervals the degree of improvement in pigmentation was reassessed with MASI scores.Effect appearance,recurrence,side-effects were also recorded.Results The 120 patients were followed for 6~12 months after treatment.118 patients(98.33%) appeared the varying degree facial pigmentation loss.5 cases(4.17%) was cured thoroughly,74 cases(61.67%) were cured better than before obviously.And in 39 cases treated for effective.The efficiency was 65.84%.37 patients(30.83%) showed clinical effect at the half-month treatment,52 patients(43.33%) showed clinical effect after one month treatment.Furthermore,only 8 patients(6.67%) had recurrences.There were no obvious side-effects of the treatment except a hypomenorrhea in 7 patients.Conclusion Ruby dot matrix laser combined with tranexamic acid tablets is a novel therapy,which is safe and effective in the treatment of melasma.更多还原