【摘要】 目的探讨体内氧化-抗氧化状态与白癜风发病的关系。方法采用化学比色法,对24例白癜风患者白斑和非白斑(正常部位皮肤)以及10例健康者组织液进行过氧化氢(H2O2)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-PX)检测。结果白癜风患者白斑H2O2水平(53.97±19.03)mmol/L明显高于健康组(28.98±22.81)mmol/L,进展期患者白斑H2O2水平(56.64±19.91)mmol/L明显高于非白斑(34.71±22.23)mmol/L,差异均有统计学意义(P均﹤0.01);白癜风白斑CAT水平(17.34±11.05)U/mL明显低于健康组(41.29±16.57)U/mL,差异有统计学意义(P﹤0.01),进展期白斑CAT水平(13.63±8.32)U/mL低于非白斑(35.72±16.14)U/mL,差异有统计学意义(P﹤0.05);进展期患者的白斑与非白斑处GSH-PX均高于健康组,差异有统计学意义(P均﹤0.05)。结论白癜风发病可能与H2O2增高、CAT降低等氧化-抗氧化失衡有关。更多还原

【Abstract】 Objective To explore the role of the oxidant-antioxidant status in the pathogenesis of vitiligo. Methods The hydrogen peroxide(H2O2),catalase(CAT)and glutathione peroxide(GSH-PX) in suction blister fluid from involved skin and uninvolved skin of 24 vitiligo patients and 10 healthy controls were detected. Results The H2O2 levels which was(53.97±19.03)mmol/L in suction blister of involved skin of vitiligo was significantly higher than those in controls which was(28.98±22.81)mmol/L(P﹤0.01). Those levels which was(56.64±19.91)mmol/L in involved skin of active vitiligo was significantly higher than those in its uninvolved skin which was(34.71±22.23)mmol/L(P﹤0.01). The CAT activities which was(17.34±11.05)U/mL of involved skin in vitiligo was significantly lower than those in controls which was(41.29±16.57)U/mL(P﹤0.01). Those levels which was(13.63±8.32)U/mL in involved skin of active vitiligo was lower than those in its uninvolved skin which was(35.72±16.14)U/mL(P﹤0.05). Both GSH-PX activities in involved skin and uninvolved skin of active vitiligo were higher than those in controls(P all﹤0.05). Conclusion Increased H2O2 levels and decreased CAT levels may play an important role in the pathogenesis of vitiligo.更多还原