【摘要】 目的:评估围术期预防性应用抗菌药物干预措施实施的可行性,促进抗菌药物的合理应用。方法:采用综合干预性研究和回顾性调查方法,以随机抽样法抽取2011年1—3月(干预前)和2011年7—9月(干预后)各100例甲状腺、乳腺外科Ⅰ类切口手术病历,对围术期预防性应用抗菌药物进行干预对照研究。结果:干预后药物选择合理率从干预前的0升至90.74%,抗菌药物使用率从干预前的100.00%下降至54.00%,首次给药时间合理率从干预前的54.00%上升至72.22%,24 h内停药病例所占比例也从干预前的24.00%上升至64.82%,患者抗菌药物平均费用从干预前的671.54元下降至44.97元。结论:对围术期预防性应用抗菌药物实施综合干预,特别是主动干预和被动干预相结合的措施具有可行性和有效性,对促进安全、有效、经济地使用抗菌药物起到了积极的作用。更多还原

【Abstract】 OBJECTIVE:To evaluate the feasibility of implementing intervention on perioperative use of prophylactic antibacterials so as to promote rational use of antibacterials.METHODS: In this intervention study & retrospective study,we randomly sampled 100 medical records during Jan.-Mar.period of 2011(before intervention) and another 100 during Jul.-Sept.period of 2011(after intervention) of patients undergoing type I incision surgery of thyroid and breast for intervention control study with regard to perioperative use of prophylactic antibacterials.RESULTS: After intervention compared with before intervention,the rate of rational choice of antibacterials peaked to 90.74% from 0.00%;the rate of antibiotic use decreased from 100.00% to 54.00%;the rate of rational initial administration time rose from 54.00% to 72.22%;the rate of antibiotic withdrawal within 24 hours rose from 24.00% to 64.82%;the average antibiotic cost per patient decreased from 671.54 yuan to 44.97 yuan.CONCLUSION: Integrated intervention of prophylactic use of antibiotics during perioperative period,particularly the combination of active and passive intervention measures,is of feasibility and effectiveness it contributes to safe,effective and economic use of antibacterials.更多还原