【摘要】 目的:分析重庆市万州区药品不良反应(ADR)发生的特点及引发ADR的相关因素,为临床合理用药提供依据。方法:对2008年6月—2010年12月1 078例ADR报告进行归纳和分析。结果:涉及药品217种,抗感染药引起的ADR为514例,占47.7%,其次为中成药和抗肿瘤药,分别为118、95例,占10.9%、8.8%;给药途径方面,以静脉注射致ADR为主,有831例,占77.1%;临床表现以全身或局部皮肤损害为最常见,有380例次,占33.8%;新的和严重的ADR共122例,占11.3%。结论:ADR的发生与多种因素有关,除科学开展ADR监测工作外,健全监督管理机制、规范操作、合理用药,可减少ADR的重复发生。更多还原

【Abstract】 OBJECTIVE:To analyze the characteristics and associated factors of the adverse drug reaction(ADR) in Chongqing Wanzhou District so as to provide references for clinical rational drug use.METHODS: A total of 1 078 ADR cases collected from Jun.2008 to Dec.2010 were analyzed statistically.RESULTS: 217 drugs were involved in the 1 078 ADR cases;514 cases(47.7%) were induced by anti-infective drugs,118 cases(10.9%) by Chinese traditional patent medicine and 95 cases(8.8%) by antineoplastic agents;831(77.1%) were induced via intravenous route;the ADR manifested predominantly as lesions of systemic or local skin [380(33%)];122(11.3%) were new or severe ADR cases.CONCLUSION: The ADR occurrence is associated with many factors.To reduce the incidence of ADR,it is necessary to carry out ADR monitoring,perfect supervision system,standardize operations and achieve rational drugs use.更多还原