【摘要】 目的比较高敏心肌肌钙蛋白(high-sensitivity cardiac troponin I,hs-cTnI)与心肌肌钙蛋白(cardiac troponin T,cTnT)对非ST段抬高型急性冠状动脉综合征(急性冠脉综合征)患者心血管事件的预测价值。方法采集103例连续的不稳定型心绞痛和非ST段抬高型急性心肌梗死患者的血浆样品,分别采用电化学发光免疫法和VITROS化学发光免疫分析法检测cTnT和hs-cTnI。采用工作者特征曲线评估心血管事件的发生率,确定hs-cTnI与cTnT的最佳预测值。结果 hs-cTnI与cTnT均能显著预测心血管事件,两者差异无统计学意义(P=0.75)。两种心脏标志物的最佳预测值分别为hs-cTnI>0.055μg/L和cTnT>0.010μg/L,敏感度均为90%,特异度均为52%;hs-cTnI阳性患者的心血管事件发生率为17%,而hs-cTnI阴性患者的心血管事件发生率为2%,两者差异有统计学意义(P=0.02)。结论 hs-cTnI与cTnT对非ST段抬高型急性冠脉综合征患者心血管事件有相似的预测诊断价值。更多还原

【Abstract】 To compare the value of high-sensitivity cardiac troponin I(hs-cTnI)versus cardiac troponin T(cTnT)for prediction of cardiovascular events in acute coronary syndromes. The plasma samples were collected from 103 patients with unstable angina or non-ST elevation acute myocardial infarction,cTnT and hs-cTnI levels were detected by electrochemiluminescence immunoassay and VITROS chemiluminescence immunoassay respectively.The prognostic value was compared to the occurrence of cardiovascular events during hospitalization. Both hs-cTnI and cTnT could significantly predict cardiovascular events and existed no significant difference(P=0.75).The best predictive value of the two cardiac markers were hs-cTnI> 0.055 μg/L and cTnT> 0.010 μg/L,the sensitivity and specificity of these two markers were 90% and 52% respectively.The incidence of cardiovascular events was 17% for hs-cTnI-positive patients and 2% for hs-cTnI-negative patients(P=0.02). Hs-cTnI and cTnT have similar predictive diagnostic value for non-ST-segment elevation acute coronary syndrome.更多还原