【摘要】 合成了4种5-氟尿嘧啶-卟啉衍生物:5-[3-(2-(5-氟尿嘧啶-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)卟啉(1a)、5-[3-(2-(5-氟尿嘧啶-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2a)、5-[3-(3-(5-氟尿嘧啶-1-基)丙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2b)和5-[3-(4-(5-氟尿嘧啶-1-基)丁氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2c),通过UV-Vis、IR、MS及元素分析表征了它们的结构。用噻唑蓝法(MTT法)测定了化合物2a、2b和2c对人胃癌细胞株BGC-823的抑制活性。化合物2b的半数抑制浓度IC50为1.34μmol/L,表明有一定的细胞毒作用。更多还原

【Abstract】 Four porphyrin-5-fluorouracil conjugates,i.e.5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)porphyrin(1a),5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2a),5-[3-(3-(5-fluorouracil-1-yl)-propoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2b) and 5-[3-(4-(5-fluorouracil-1-yl)-butoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2c),were successfully synthesized and characterized by UV-Vis,IR,MS and elemental analysis.Inhibition activity of the synthesized compounds(2a,2b and 2c) to human gastric cancer cell line BGC-823 was tested using the methyl thiazolyl tetrazolium(MTT) method.The IC50 value of 2b was 1.34 μmol/L,indicating that compound 2b had certain cytotoxic effect.更多还原