【摘要】 以取代苄胺或伯胺为原料,依次经过Michael加成、Dieckmann缩合、水解脱羧和羟醛缩合反应,合成了10种新化合物(8a～8j),目标化合物的结构经1H NMR、IR、MS和元素分析确证。初步的MTT法生物活性测试表明,目标化合物在100 mg/L浓度下能有效抑制白血病K562细胞、乳腺癌HO8910PM细胞和卵巢癌MDR-MB-231细胞的增殖,具有潜在的抗癌活性。更多还原

【Abstract】 A series of novel N-(substituted benzyl)-3,5-bis(benzylidene)-4-piperidones(8a~8j) were synthesized uisng substituted benzylamines as precursors via a series of Michael addition,Dieckmann condensation,hydrolysis decarboxylation and Aldol condensation.The structures were confirmed by 1H NMR,IR,MS and elemental analysis.The preliminary biological activity tests by MTT assay indicated that some of the target compounds had good antiproliferative activities against K562,MDR-MB-231 and HO8910PM cells,and therefore showed potential anti-tumors bioactivity.更多还原