【摘要】 目的研究中国朝鲜族和汉族健康受试者单剂量口服马来酸氟吡汀的药动学。方法选择健康受试者20例(朝鲜族和汉族各10例),单剂量口服马来酸氟吡汀胶囊100 mg后,用高效液相色谱-荧光检测法测定血浆中马来酸氟吡汀浓度,研究其药动学过程。结果朝鲜族和汉族受试者口服马来酸氟吡汀后半衰期(t1/2)分别为(7.72±0.85),(8.85±2.15)h;达峰时间(tmax)分别为(2.35±2.06),(1.70±0.79)h;峰浓度(Cmax)分别为(1 012.73±376.16),(1 078.09±296.74)μg.L-1;血药浓度-时间曲线下面积(AUC0-36)分别为(8 552.69±1 773.64),(8 406.24±1 622.50)μg.L-1.h;AUC0-∞分别为(8 914.96±1 890.04),(8 971.71±1 996.53)μg.L-1.h;两组均差异无统计学意义(P>0.05)。结论口服马来酸氟吡汀后,汉族、朝鲜族受试者各主要药动学参数之间差异无统计学意义。更多还原

【Abstract】 Objective To investigate the pharmacokinetics of flupirtine maleate in Chinese Korean and Han healthy volunteers.Methods Ten Chinese Korean and 10 Han volunteers(the ratio of male:female at 1:1) were enrolled in this study.Each subject received a single oral dose(100 mg) of flupirtine maleate respectively.Blood samples were determined by HPLC-fluorescence method and the pharmacokinetic parameters were calculated by Das Ver 2.0 software.Results The main pharmacokinetic parameters of Chinese Korean and Han were as follows: t1/2(7.72±0.85) and(8.85±2.15) h;tmax(2.35±2.06) and(1.70±0.79) h;Cmax(1 012.73±376.16) and(1 078.09±296.74) μg·L-1;AUC0-36(8 552.69±1 773.64) and(8 406.24±1 622.5) μg·L-1·h;AUC0-∞(8 914.96±1 890.04) and(8 971.71±1 996.53) μg·L-1·h,respectively.Conclusion The pharmacokinetic parameters obtained from our study showed no significant difference between Chinaese Korean and Han(P>0.05).更多还原