【摘要】 目的探讨高良姜素对D-半乳糖致衰老小鼠学习记忆能力的改善作用。方法皮下注射D-半乳糖制备小鼠衰老模型。用Morris水迷宫和电跳台法测试小鼠的学习记忆能力,用生物化学方法测定大脑海马超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶(CAT)活性和丙二醛(MDA)含量。结果与正常对照组比较,模型组学习记忆能力减退,大脑海马SOD、GPx、CAT活性降低,MDA含量增高。与模型组比较,高良姜素高、低剂量组均能显著改善衰老小鼠学习记忆能力,提高小鼠海马内SOD、GPx、CAT活性,降低MDA含量。结论高良姜素能显著改善D-半乳糖致衰老小鼠学习记忆能力,提高大脑海马区SOD、GPx、CAT活性,降低MDA的含量,具有较好的抗氧化能力。更多还原

【Abstract】 Objective To investigate the effect of galangin(GL) on cognitive impairment in the senescent mice induced by D-galactose(D-gal).Methods D-gal was subcutaneously injected to establish a senescent mice model.The Morris water maze test and step-down avoidance one were performed to study the learning and memory abilities of mice.The activities of superoxide dismutase(SOD),glutathione peroxidase(GPx),catalase(CAT) and content of malondialdehyde(MDA) in mice hippocampus were detected by biochemical examination.Results The mice treated with D-gal generated significant cognitive deficiency.Administration of GL to D-gal treated mice ameliorated cognitive impairment in the hippocampus.Biochemical examination revealed that GL attenuated the decreased activities of SOD,GPx,CAT and reduced MDA levels in the hippocampus of D-gal-treated mice.Conclusion Galangin possesses anti-oxidative effect by improving the cognitive function,and increasing activities of SOD,GPx,CAT and lowering MDA of the senescent mice induced by D-gal.更多还原