【摘要】 目的观察甲状腺机能亢进(Graves病)并糖代谢紊乱患者甲亢控制后血糖、血清胰岛素、胰岛素敏感指数变化,了解甲亢状态时,超生理浓度的甲状腺激素对胰岛β细胞分泌功能、胰岛素敏感性的影响。方法对比32例Graves病并糖代谢紊乱患者甲亢控制后前后血糖、胰岛素水平及胰岛素敏感指数的变化。结果 112例Graves患者合并糖代谢紊乱32例,合并糖代谢紊乱的发生率为28.57%;治疗前后空腹血糖(FPG)及甲状腺激素水平(FT3、FT4)比较差异均有统计学意义(均P<0.05);PPG治疗后较治疗前有下降,但差异无统计学意义(P>0.05);治疗前后胰岛素水平(FINS、PINS)及胰岛素敏感指数(HOMA-IR、HOMA-IS)比较差异均有统计学意义(P<0.05)。结论Graves病并糖代谢紊乱患者存在胰岛β细胞分泌功能降低及外围胰岛素抵抗,甲亢控制后,有利于胰岛素敏感指数的改善。更多还原

【Abstract】 Objective To observe the changes of blood glucose,serum insulin,insulin sensitivity index of hyperthyroidism controlling in the patients with Graves’ disease and glucose metabolism,understudied the super-physiological concentrations of thyroid hormones on the impact of islet β-cell function and insulin sensitivity.Methods The changes of blood glucose,serum insulin,insulin sensitivity index were compared before and after hyperthyroidism controlling.Results 18 cases had been glucose metabolism in 112 cases with Graves’ disease,the incidence of glucose metabolism was 16.07%;there were significant differences in FPG and thyroid hormone levels(FT3,FT4) before and after the treatment(P < 0.05);PPG had been dropped after treatment,however,the difference had no significant differences(P > 0.05);there were significant differences in insulin levels(FINS,PINS) and insulin sensitivity index(HOMA-IR,HOMA-IS) before and after the treatment(P < 0.05).Conclusion The patients with Graves’ disease and glucose metabolism have the drop of β-cell function and resistance of peripheral insulin,and the hyperthyroidism controlling is conducive to the improvement of insulin sensitivity index.更多还原