【摘要】 目的分析抗菌药物不良反应(ADR)发生的特点及临床表现,为临床合理用药提供参考。方法采用Excel2003软件对山东省立医院2010年上报的271份抗菌药物ADR报告表进行回顾性分析。结果 271例ADR共涉及抗菌药物10类41种药品。在不同种类抗菌药中,喹诺酮类引起ADR的例数最多,为62例(22.88%),其次是头孢菌素类44例(16.23%)和硝咪唑类41例(15.13%)。在不同品种抗菌药物中,左氧氟沙星引起ADR的例数最多,为43例(15.87%),其次是奥硝唑和阿奇霉素,分别为40例(14.76%)和30例(11.07%)。结论医院应加强ADR监测工作,为临床合理应用抗菌药物提供依据。更多还原

【Abstract】 Objective To analyze the characteristics and clinical manifestation of antimicrobial adverse drug reaction(ADR),in order to provide reference for clinical rational drug application.Methods 271 cases of ADRs which were caused by antimicrobial agents of Shandong provincial hospital in 2010 were analyzed retrospectively by Excel 2003 software.Results 10 categories 41 kinds of antimicrobial drugs were involved in the total 271 cases of ADRs.Among different categories of antimicrobial,the ADRs were mainly induced by Quinolones,62 cases(22.88%) of ADRs were associated with it;Cephalosporins and Nitroimidazoles were followed,which had 44 cases(16.23%) and 41 cases of ADRs(15.13%).Among different kinds of antimicrobial,the greatest number of ADR were caused by Levofloxacin,43 cases(15.87%) were included;Ornidazole and Azithromycin were followed,40 cases(14.76%) and 30 cases(11.07%) were included respectively.Conclusion The monitoring of ADRs should be strengthened in hospital,in order to provide basis for clinical rational antimicrobial application.更多还原