【摘要】 急性T淋巴细胞性白血病(T-ALL)是一种具有高侵袭性特征的恶性血液肿瘤,建立稳定的动物模型是研究其发病机制及进行潜在治疗药物的前临床研究的重要前提。日益广泛应用的稳定的T-ALL小鼠动物模型主要有小鼠的异种移植模型和转基因小鼠模型。现就T-ALL的小鼠异种移植模型从小鼠品系、移植用细胞株、建模方式及模型的应用进行综述。更多还原

【Abstract】 T-ALL(T-cell acute lymphoblastic leukemia)is an aggressive haematopoietic malignancy.Identification of the pathogenesis of T-ALL and the preclinical trial of potential therapeutic protocols rely most heavily on stable and reliable murine models.In recent research,murine xenotransplantation models and transgenic mouse models are obtaining more and more attention and application.Here is to make a review on establishment of T-ALL murine models from the mice category,cell lines,engraftment methods and the applications respectively.更多还原