【摘要】 硫化氢(H2S)已成为第三种内源性气体信号分子。H2S由胱硫醚-β-合酶、胱硫醚-γ-裂解酶和3-巯基丙酮酸转硫酶三种酶产生。呼吸节律产生于中枢神经系统脑干延髓的一个局限区域——前包钦格复合体,生理浓度的H2S对中枢性呼吸节律有"先抑制后兴奋"的双向调节作用,而高浓度H2S对呼吸节律产生抑制作用。H2S可能是通过KATP通道和环磷酸腺苷途径参与呼吸中枢节律性调控。更多还原

【Abstract】 Hydrogen sulfide(H2S) has emerged as the third endogenous gaseous mediator.H2S is generated by three enzymes:cystathionine-β-synthase(CBS),cystathionine-γ-lyase(CSE) and 3-mercaptopyruvate sulfurtransferase(3MST).Respiratory rhythms are generated from a limited area-pre-Bntzinger complex(Pre-BtC),of medulla oblongata.H2S of physical concentration regulates bilaterally respiratory center rhythms through "first depression and then excitation".H2S of high concentration,however,depresses respiratory rhythms.H2S possibley regulates respiratory center rhythms through KATP channel and cyclic adenosine monophosphate(cAMP) pathway.更多还原