【摘要】 目的检测并研究食管癌患者血浆中纤维蛋白原(FIB)和D-二聚体(D-dimer,DD)的变化及其临床意义。方法对60例食管癌患者和8例健康人血浆中FIB和D-二聚体进行检测并同临床指标间进行统计学分析。结果食管癌组血浆中的FIB和D-二聚体水平明显高于正常对照组(P<0.01);同患者的淋巴结转移情况及P-TNM分期有关(P<0.05或P<0.01),而同性别及年龄不相关(P>0.05)。结论食管癌患者的FIB及D-二聚体高于正常,并同淋巴结转移及P-TNM分期相关且与患者的生存期呈明显的负相关。更多还原

【Abstract】 Objective To explore the clinical significance of fibrinogen and D-dimer detection in esophageal squamous cell cancer.Methods The fibrinogen and D-dimer were detected in 60 esophageal cancer patients and 8 healthy adults,and the data were analyzed with clinical indexes by SPSS.Results Levdel of fibrinogen and D-dimer in esophageal cancer patients were higher than that in healthy group(P<0.01).There was relationship between fibrinogen and D-dimer levels and lymph node metastases and p-TNM stage(P<0.05 or P<0.01).Otherwise,there was no relationship between fibrinogen and D-dimer levels and sex and age(P>0.05).Conclusion Compared with healthy group,significantly higher serum fibrinogen and D-dimer levels were detected in esophageal cancer patients.There was closely relationship between fibrinogen and D-dimer levels in esophageal cancer patients and lymph node metastases,p-TNM stage,and they were negatively correlated with lifetime.更多还原