【摘要】 目的观察胆碱能激动剂氧化震颤素对精氨酸加压素(AVP)引起大鼠低温反应的影响及其与环境温度变化的关系。方法用无线遥控测温技术连续同步记录成年雌性SD大鼠体核温度(Tc)和活动变化。在中性(25℃)、热(30℃)和冷(18℃)环境中,分别观察AVP(10μg/kg)和氧化震颤素(0.25mg/kg)对大鼠Tc和活动的影响。结果分别给置于25℃、30℃和18℃环境中的大鼠注射AVP或氧化震颤素后,均能引起大鼠Tc迅速降低,但18℃环境中Tc的降低比25℃和30℃更明显。3种环境温度中,氧化震颤素均能使AVP引起的低温反应更明显,并持续更长时间。但18℃环境中,氧化震颤素增强AVP引起低温反应的作用明显大于25℃和30℃。结论①AVP引起的低温可能与体温调定点下移有关,因为在冷环境中AVP引起的低温反应更明显;②氧化震颤素能够增强AVP引起的大鼠低温反应,此作用在冷环境中最明显,提示氧化震颤素可能通过影响体温调定点参与AVP引起的低温反应。更多还原

【Abstract】 Objective To investigate the effects of cholinergic agonists oxotremorine on arginine vasopressin(AVP)-induced hypothermia in rats and its relationship with ambient temperature changes.Methods Core temperature(Tc) and motor activities were monitored in undisturbed female SD rats using radiotelemetry.Effects of AVP(10μg/kg) and oxotremorine(0.25mg/kg) on Tc and motor activities were observed at ambient temperature of neutral(25℃),warm(30℃) and cold(18℃),respectively.Results Administration of AVP or oxotremorine alone caused a significant drop in Tc at ambient temperatures of 25℃,30℃ and 18℃,respectively.But at ambient temperature of 18℃,Tc was lower than at 25℃ and 30℃.AVP-induced hypothermia was augmented by oxotremorine and lasting a longer time at different ambient temperatures.Furthermore,at ambient temperature of 18℃,the effect of oxotremorine to augment AVP-induced hypothermia was more obvious than at 30℃ and 25℃.Conclusion The hypothermic effects of AVP may be related with the set-point temperature reduction,because AVP-induced hypothermia was greatest at cold ambient temperature;The effect of oxotremorine to augment AVP-induced hypothermia was greatest at cold ambient temperature,which indicated that oxotremorine appeared to participate in AVP-induced hypothermia by affecting set point temperature.更多还原