【摘要】 目的通过双侧颈总动脉、颈内动脉及锁骨下动脉内中膜厚度的测定及比较,判断原发性醛固酮增多症是否会对血管造成更严重的损伤。方法选取77名原发性高血压(essential hypertension,EH)患者,及77名原发性醛固酮增多症(primaryaldosteronism,PA)患者,年龄分别为EH组45±6岁;PA组48±9岁,行颈动脉超声检查,测量双侧颈总动脉、颈内动脉及锁骨下动脉内中膜厚度。结果 PA组颈动脉内中膜厚度与EH组相比明显增厚,且差异具有统计学意义(P均<0.05)。相关分析结果表明颈部血管内中膜厚度与血浆醛固酮浓度呈正相关(P均<0.05)。结论原发性醛固酮增多症患者颈动脉内中膜厚度较之原发性高血压患者厚,说明原发性醛固酮增多症患者血管损害较原发性高血压严重。更多还原

【Abstract】 Objective To investigate whether vascular damage could be more serious in priary aldosteronism(PA) compared with essential hypertensive patients(EH) through measuring the intima-media thickness(IMT) of carotid artery.Methods Totally 77 cases diagnosed PA and 77 patients with EH were selected.An average age in PA group was 48±9 years old and that of EH group was 45±6 years.IMT of bilateral common carotid artery,internal carotid artery and the subclavian artery were measured by Doppler ultrasonography.Results The patients with primary aldosteronism had significantly higher IMT of the common carotid artery than patients with essential hypertension(P<0.05).There was positive correlation between carotid IMT and plasma aldosterone concentrations(P<0.05).Conclusion IMT of common carotid in patients with primary aldosteronism was higher than that of essential hypertensives.A likely explanation for the results is the deleterious effects of excess aldosterone which would cause the fibrosis and thickening of the arterial wall,especially in the straight segments of vessels.更多还原