【摘要】 目的探讨白介素-10基因-819 C>T位点多态性与膀胱癌易感性的关系。方法以病例对照研究方法,应用等位基因特异性PCR(AS-PCR)分别检测400例膀胱癌患者和400例健康体检者的IL-10-819 C﹥T基因多态性,对各基因型和等位基因进行统计学分析。结果膀胱癌组变异纯合TT基因型的频率(54.5%)高于对照组基因型(42.0%),差异有统计学意义[χ2=4.740,P<0.05,OR=1.977(95%CI:1.064～3.674)],膀胱癌组携带变异T等位基因的频率(72.0%)高于对照组基因型(63.0%),差异有统计学意义[χ2=7.385,P<0.01,OR=1.510(95%CI:1.121～2.035)];IL-10-819 C>T的基因型频率在浅表型和浸润型膀胱癌之间无统计学意义。结论 IL-10-819 C﹥T基因多态性与浙江汉族人群膀胱癌易感性有关。更多还原

【Abstract】 Objective To investigate the association between genetic polymorphism of the Interleukin-10-819 C﹥T and susceptibility of bladder cancer.Methods Based upon a case-control study,the polymorphisms of Interleukin-10-819 C﹥T were determined by allele specific PCR amplification(AS-PCR) in 400 cases with bladder cancer and 400 healthy controls.The genotypes of IL-10-819 C>T and the risk of bladder cancer were analyzed.Results The frequency of variant homozygous TT genotype in cases with bladder cancer(54.5%) was higher than that in healthy controls(42.0%) and difference was statistically significant [χ2=4.740,P<0.05,OR=1.977(95%CI:1.064-3.674)].The frequency of variant allele T in cases with bladder cancer was higher than that in healthy controls(72.0%,63.0% respectively) and the difference was statistically significant [χ2=7.385,P<0.01,OR=1.510(95%CI:1.121-2.035)].There was no association of the genotypes of IL-10-819 C﹥T with the clinical stage of bladder cancer.Conclusions The genetic polymorphisms of Interleukin-10-819 C﹥T were associated with the susceptibility of bladder cancer among Han nationality in Zhejiang.更多还原