【摘要】 目的探讨单纯舒张期高血压(IDH)患者的临床特点及血管活性物质的关系。方法研究对象共80例,包括60例IDH患者(IDH组)和无高血压病相同年龄的健康人20例(对照组)。分别监测血压,检测血浆血管活性物质肾上腺髓质素(ADM)、前列环素(PGI2)、血管紧张素Ⅱ(AT2)及血栓素A2(TXA2)的浓度水平并进行比较。结果 IDH组与对照组比较,年龄和性别无显著差异外,舒张压、体重指数、尿酸、肌酐两组间均有显著性差异(P<0.05)。ADM、PGI2、AT2、TXA2含量在IDH组与对照组比较有显著性差异(P<0.05)。结论 IDH患者体重指数、尿酸、肌酐较正常对照高,IDH患者的血浆ADM、PGI2、AT2和TXA2的含量也较正常人群为高,提示IDH存在血管活性物质水平改变。更多还原

【Abstract】 Objective To explore the relationship of vasoactive substances and clinical symptoms in IDH patients.Methods We collect 80 patients′ data and plasma,including 60 IDH patients and 20 healthy persons with the same age as control.Then we monitor their blood pressure,detect and compare the level of several vasoactive substances in plasma,such as adrenomedullin(ADM),prostacyclin(PGI2),angiotensin Ⅱ(AT2) and thromboxane A2(TXA2).Results Compared with the control group,IDH patients′ diastolic pressure,body mass index,blood uric acid and blood creatinine are significantly increased(P<0.05).Moreover,the levels of ADM,PGI2,AT2 and TXA2 in IDH patients′ plasma are statistical elevated against the control(P<0.05).Conclusion Our results suggest that these vasoactive substances may be important regulators to induce IDH.As important biomarkers,they probably predict the occurrence of IDH.更多还原