【摘要】 目的大肠癌(colorectal cancer,CRC)的流行病学特征是随着时间和地区的变化而变化。本研究通过比较分析广东省湛江地区1996～2000年与2006～2010年两个时期的1290例大肠癌病例的临床病理特征,从而了解湛江地区大肠癌的发病特点和变化规律。方法收集广东医学院附属医院1996～2000年与2006～2010年两个时期收治病理确诊的长期在湛江地区居住的大肠癌患者1290例的临床资料进行统计学分析。结果 1996～2000年与2006～2010年比较,大肠癌的男女比例从1.62降至1.46;乡村患者从64.9%上升至71.2%(χ2=5.513,P=0.013);右侧结肠癌从21.1%增至27.4%,而左侧结肠癌与直肠癌分别从24.6%、54.2%降至21.5%、51.1%(χ2=6.491,P=0.039);黏液腺癌病例均较多(23.1%,23.3%)。结论湛江地区大肠癌可能有发病率上升、好发部位右移的趋势,黏液腺癌与肠梗阻较多。应加强居民的健康教育,提高疾病预防意识。更多还原

【Abstract】 Objective Clinical epidemiology of colorectal will be changed along with time and region.In order to clarify clinical epidemiology of Zhanjiang region,we analyzed comparatively 1290 patients with colorectal cancer between 1996-2000 and 2006-2010.Methods We collected 1290 patients who were permanent residents in Zhanjiang region with colorectal cancer from Affiliated Hospital of Guangdong Medical College in 1996-2000 and 2006-2010.Results When comparing patients in 1996-2000 with those in 2006-2010,ratio of male to female decreased from 1.62 to 1.46,percent of country patients increased from 64.9% to 71.2%(χ2=5.513,P=0.013),right-sided colon cancer increased from 21.1% to 27.4%,while left-sided colon cancer and rectum cancer decreased from 24.6%,54.2% to 21.5%,51.1% respectively(χ2=6.491,P=0.039).Conclusion The incidence of colorectal cancer in Zhanjiang region may have an increasing tendency.A proximal shift in the anatomical distribution of colorectal cancer has occurred.Furthermore,mucinous adenocarcinoma and bowel obstruction were more common in this region.Thus healthy education and colorectal cancer prevention should be strengthened.更多还原