观察宁夏地区栽培甘草(Glycyrrhiza uralensis Fisch.)中获得的甘草总黄酮提取部位(licorice flavonoids,LF)对大鼠慢性不可预见性应激抑郁模型(chronic unpredicted stress model of depression,CUS)的干预作用及对模型造成的海马齿状回(dentate gyrus,DG)颗粒细胞层下区(subgranular zone,SGZ)神经再生(neurogenesis)能力损害的保护作用,研究LF抗抑郁作用及可能的机制。通过对大鼠实施9种不同的刺激建立慢性应激抑郁模型,造模28天的同时采用不同剂量的LF(300、100和30 mg.kg-1)连续干预。采用旷场实验(open field test,OFT)、强迫游泳实验(forced swimming test,FST)和悬尾实验(tail suspension test,TST)判断LF的抗抑郁作用,放免法测定血清皮质酮含量,共聚焦显微镜对海马齿状回SGZ中5-溴脱氧尿嘧啶核苷(5'-bromo-2'-deoxyuridine,BrdU)标记的新生祖细胞(progenitor)...
【英文摘要】
Adult rats chronic unpredictable stress model of depression(CUS) was adopted to elucidate the antidepressant pharmacological activity and related neurogenesis protective effect of the total flavonoids extract(licorice flavonoids,LF) from the Glycyrrhiza uralensis Fisch.cultivated locally in Ningxia.The rats were exposed to 9 kinds of unpredictable sequence of stressors and were given flavonoids(300 mg·kg-1,100 mg·kg-1 and 30 mg·kg-1) for 28 days.The antidepressant effect was elucidated by open field test,fo...
【基金】
国家自然科学基金资助项目(81060113)
【更新日期】
2012-12-25
【分类号】
R285.5
【正文快照】
Antidepressant activities of flavonoids from Glycyrrhizauralensis and its neurogenesis protective effect in ratsFAN Zi-zhou1,ZHAO Wei-hong1,GUO Jia1,CHENG Rui-feng1,ZHAO Jin-ying1,YANG Wei-dong1,WANG Ying-hua2,LI Wei3,PENG Xiao-dong1*(1.School of Basic Me
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