【摘要】 目的:研究对比单纯腺性膀胱炎电切术以及术后加用丝裂霉素膀胱内灌注化疗对预防复发及癌变的疗效。方法:103例行膀胱镜活检病理证实为腺性膀胱炎的患者,分为两组,实验组:53例,经尿道电切术后行丝裂霉素膀胱灌注;对照组:50例,仅单纯电切,术后均口服第三代喹诺酮类抗生素1周;比较两组患者术后总有效率,复发率及观察丝裂霉素膀胱内灌注不良反应。结果:随访7～63个月,平均35个月,治疗组:总有效率为86.8%(46/53),复发率6.5%(3/46);对照组:总有效率为74%(37/50),复发率16.2%(6/37)。两组总有效率及复发率比较差异有统计学意义(P<0.05)。丝裂霉素主要不良反应为尿频、尿急、尿痛等膀胱刺激症状,很少有因骨髓抑制、肝肾毒性而引起的严重并发症。结论:腺性膀胱炎电切术后应用丝裂霉素膀胱内灌注,能明显提高腺性膀胱炎治疗有效率,减少复发,且不良反应少,安全性较高。更多还原

【Abstract】 Objective:To study the contrast of simple cystitis glandularis electrocision,and postoperative intravesical chemotherapy with mitomycin,two groups of treatment to prevent relapse and canceration,curative effect.Methods:103 cases cystoscopy biopsy confirmed cystitis glandularis patients,divided into two groups,the experimental group:53 patients after transurethral resection of bladder instillation of mitomycin,control group:50 cases.Only electric cutting,postoperative mean oral third generation quinolone antibiotic 1 week,comparison of the two groups of patients after total efficiency,the recurrence rate and observation of mitomycin intravesical adverse reaction.Results:Follow-up of 7～ 63 months,an average of 35 months,the treatment group: the total effective rate was 86.8%(46/ 53),the recurrence rate was 6.5%(3/46);control group: the total effective rate was 74%(37/50),the recurrence rate was 16.2%(6/ 37).Two groups of the total efficiency and recurrence rate had a significant difference(P<0.05).MMC main adverse reactions as urinary frequency,urgency,dysuria,urinary bladder irritation symptoms,there are few due to inhibition of bone marrow,liver and kidney toxicity caused by severe complication.Conclusion:Cystitis glandularis after transurethral resection of bladder instillation of mitomycin,can significantly improve the treatment of cystitis glandularis efficiency,reduce the recurrence,and less adverse reaction,high security.更多还原