【摘要】 目的比较艾迪注射液联合化疗与单纯化疗对肺癌的疗效、毒副反应及免疫功能的影响。方法将62例肺癌患者随机分为2组。观察组:在化疗开始起同时应用艾迪注射液,每次100ml加入0.9%氯化钠注射液500ml静脉滴注,每天1次,连用10d。对照组:单纯化疗。化疗方案均为重酒石酸长春瑞滨注射液加顺铂(NP)方案。结果观察组有效率43%,对照组为25%,差异有统计学意义(P<0.05)。观察组病变进展率、血液毒副作用、不良反应均明显低于对照组,差异有统计学意义(P<0.05)。观察组化疗后细胞免疫功能及自然杀伤细胞(NKT)活性均有显著增加(P<0.05)。结论艾迪注射液联合化疗治疗肺癌,可降低化疗对患者免疫功能的影响及毒副反应,改善NKT细胞活性。更多还原

【Abstract】 Objective To compare the efficacy, adverse events and immunity in patients treated with chemotherapy alone or in combination with Aidi injection. Methods Sixty-two consecutive patients with lung cancer were randomly assigned to receive chemotherapy (NP protocol) alone (control group) or in combination with Aidi injection intravenously (100 ml dissolved in 500 ml 0.9% natural saline) once daily for 10 consecutive days (observation group), respectively. Results The observation group presented higher (P<0.05) effectiveness rate (43%) than control group (25%). Considerably lower rate of progression, hematologic side-effects and adverse events were associated with observation group (P<0.05), but not control group. Additionally, observation group yielded marked increase in cellular immunity and natural killer cell activity (P<0.05). Conclusion The combination of Aidi injection and chemotherapy may be correlated with reduced adverse impacts on immunity, minor side-effects and improved natural killer cell activity in patients with lung cancer.更多还原