【摘要】 目的:了解抗菌药物药品不良反应(ADR)的发生特点和规律。方法:对本院2008年1月～2011年12月收集到的438例抗菌药物ADR报告进行回顾性分析。结果:女性ADR发生率(56.39%)高于男性(43.61%);药师上报ADR报告209例(47.72%);静脉给药(79.00%)是引起ADR的主要给药途径;所有ADR报告中,氟喹诺酮类(128例)和大环内酯类(112例)最多;ADR的临床表现主要为过敏样反应(32.21%)和胃肠道反应(24.65%),其次是注射部位局部刺激(13.12%)。结论:应重视抗菌药物不良反应的监测,为临床合理用药提供参考。更多还原

【Abstract】 Objective:To investigate the characteristics and regularity of anti-infective adverse drug reactions(ADR).Methods:438 cases of antibacterial ADR collected from January 2008 to December 2011 were analyzed retrospectively.Results:Of all antibacterials ADR cases,the incidence rate of ADR was obviously higher in females(56.39%) than that in males(43.61%).209 ADR cases(47.72%) were reported by pharmacists.Intravenous route(79.00%) was the most common route among all ADR cases.Fluoroquinolones(128 cases) and macrolides(112 cases) were the most common drugs in 438 cases with ADR.The main clinical manifestations were skin allergic response(32.21%) and gastrointestinal reaction(24.65%),as well as localized stimulus of injection site(13.12%).Conclusion:More attention should be paid to the monitoring of antibacterial ADR for the clinical rational drug usage.更多还原