【摘要】 银屑病是一种炎症过度增生性皮肤病,有强烈的遗传易感性,主要受到遗传、免疫和环境的影响。由于大部分患者病情处于轻中度,所以相比全身治疗,局部治疗具有费用低、用药方便且安全性高的特点,因此具有更大的临床意义。然而,目前涉及银屑病局部治疗的遗传药理学研究却很少。本文主要对近几年银屑病局部治疗反应和遗传因素的关系进行一个较为全面的综述,以期为银屑病患者的个体化医学提供理论指导。更多还原

【Abstract】 Psoriasis is an inflammatory hyperproliferative skin disease with a strong genetic susceptibility and influenced by genetic,immunological and environmental factors.Because the topical treatment is characterized of low cost,proper efficiency and high safety,it is commonly selected for most patients with mild to moderate psoriasis.However,the pharmacogenetics studies on the topical treatment are sparse.This review summarizes the correlations between genetic factors and topical agents to provide the theoretical guidance for the personalized medication in psoriasis.更多还原