【摘要】 目的观察低蛋白饮食联合复方α-酮酸对维持性血液透析(MHD)患者钙磷代谢紊乱的影响。方法 MHD患者80例随机均分为两组:治疗组给予低蛋白饮食联合复方α-酮酸;对照组给予正常蛋白饮食。检测治疗前和治疗1、3个月血清钙、磷、甲状旁腺激素(iPTH)、白蛋白(Alb)和前白蛋白(PA)。结果治疗组治疗1、3个月后的血磷分别为(1.81±0.12)mmol/L和(1.79±0.13)mmol/L,明显低于治疗前的(2.27±0.14)mmol/L和对照组的(2.31±0.09)mmol/L和(2.28±0.12)mmol/L(P<0.05);治疗3个月,治疗组血清iPTH为(174.1±71.2)pg/ml,明显低于治疗前的(411.2±98.3)pg/ml(P<0.05)。结论低蛋白饮食联合复方α-酮酸可有效降低MHD患者的血磷和血清iPTH。更多还原

【Abstract】 Objective To investigate the effects of low protein diet combined with α-keto acid on the disorder of calcium and phosphorus metabolism in patients undergoing maintanence hemodialysis(MHD).Methods Eighty MHD patients were equally randomized into two groups of A(treated with low protein diet combined with α-keto acid) and B(treated with normal protein diet).Serum calcium,phosphorus,intact parathyroid hormone(iPTH),albumin and prealbumin(PA) were detected before and on the 1st and 3rd month of therapy.Results Serum concentrations of phosphorus on the 1st and 3rd month of therapy in group A were(1.81±0.12) mmol/L and(1.79±0.13) mmol/L,which were lower than(2.27±0.14) mmol/L before and(2.31±0.09) mmol/L and(2.28±0.12) mmol/L in group B(P<0.05).Serum iPTH on the 3rd month of therapy in group A was(174.1±71.2) pg/ml,which was lower than(411.2±98.3) pg/ml before(P<0.05).Conclusion Low protein diet combined with α-keto acid can effectively decrease phosphorus and iPTH in serum.更多还原