【摘要】 慢性肾脏病(chronic kidney disease,CKD)早期即可出现胰岛素抵抗(insulin resistance,IR)和高胰岛素血症,炎症、氧化应激、血管紧张素Ⅱ的激活、肥胖、活性维生素D缺乏、甲状旁腺功能亢进、贫血等因素可影响胰岛素分泌,诱发IR的发生发展。IR和高胰岛素血症又可通过几个途径直接或间接损伤肾脏。IR与慢性肾病互为因果,是近年的研究热点。更多还原

【Abstract】 Insulin resistance and hyperinsulinmia could happen at early stage of chronic kidney disease. Inflammation, oxidative stress, angiotesin II, obesity, deficiency of 1, 25-dihydroxyvitamin D, hyperparathyroidism and anemia can influenc the secretion of insulin and induce insulin resistance. Insulin resistance induces kidney damage directly and indirectly by different mechanisms. Insulin resistance and chronic kidney disease interact as both cause and effect.更多还原