【摘要】 目的:探讨曲米他嗪辅助治疗冠心病合并2型糖尿病心衰临床疗效。方法:选择2010年5月至2011年2月在我科就诊的冠心病合并2型糖尿病心衰患者68例作为研究对象,随机将其分为观察组和对照组各34例。两组患者均进行糖尿病饮食控制,对照组予以常规治疗药物,包括地高辛、利尿剂、血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂、硝酸脂类及β受体阻滞剂;观察组在对照组常规治疗基础上加用曲美他嗪。结果:观察组总有效率为88.24%,对照组总有效率为67.65%,两组总有效率比较差异有统计学意义(P<0.05);观察组在心功能改善方面显著优于对照组(P<0.05);两组患者治疗后均使CRP和BNP水平降低,但观察组变化与对照组比较差异有显著性(P<0.01)。结论:应用曲美他嗪治疗冠心病合并2型糖尿病心衰患者能够优化心肌代谢,也能有效抑制冠心病心衰患者炎症反应及改善心功能。更多还原

【Abstract】 Objective:To investigate the efficacy of trimetazidine supplementation in treatment for coronary artery disease combining type 2 diabetes related heart failure.Methods:68 cases of coronary artery disease combining type 2 diabetes related heart failure checked in between May 2010 and February 2011 were randomly and evenly divided into observation group and control group,34 cases each.Both groups had their diet controlled.The control group was treated conventionally with digoxin,diuretics,angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists,nitric acid lipids and β receptor blockade agent while the observation group was supplemented with trimetazidine in addition to conventional medicine.Results:The total effective rate was 88.24% in the observation group,and 67.65% in control group;the difference was significant(P < 0.05) and observation group showed better results.CRP and BNP levels of both groups decreased but they had significant difference between(P < 0.01).Conclusion:In the treatment for coronary artery disease combining type 2 diabetes related heart failure,trimetazidine can improve myocardial metabolism,effectively inhibit inflammation,and improve heart function.更多还原