【摘要】 目的 探讨一氧化氮合酶1转接蛋白(NOS1AP)基因多态性与中国淮海地区汉族人群2型糖尿病发病风险的关系。方法 采用聚合酶链式反应-限制性片断长度多态性(PCR-RFLP)方法对200例2型糖尿病患者(病例组)和200例健康人群(对照组)进行NOS1AP基因多态性检测。结果 病例组NOS1AP rs12742393位点CC基因型和C等位基因频率均高于对照组(P <0.05),C等位基因显著增加2型糖尿病的遗传风险性(OR=1.662,95%CI=1.089～2.535,P=0.018)。结论 NOS1AP rs12742393位点多态性可能与中国淮海地区汉族人群2型糖尿病的发病相关,C等位基因可能是2型糖尿病的遗传风险因子。更多还原

【Abstract】 Objective To investigate the correlation between nitric oxide synthase 1 adaptor protein(NOS1AP)gene polymorphism and risk of type 2 diabetes mellitus in Chinese Han population from Huaihai region.Methods The gene polymorphisms of 200 type 2 diabetes mellitus patients(case group) and 200 healthy subjects(control group) were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results CC genotype frequency and C allele frequency of NOS1AP rs12742393 in case group were higher than those in control group(P <0.05).There was significantly difference between the two groups.The C allele significantly increased the genetic risk of type 2 diabetes mellitus(OR=1.662,95% CI=1.089-2.535,P=0.018).Conclusions NOS1AP rs12742393 polymorphism may be associated with the incidence of type 2 diabetes mellitus among Chinese Han population from Huaihai region,C allele may be the genetic risk factor for type 2 diabetes mellitus.更多还原