【摘要】 目的 探讨大肠癌组织中特异AT序列结合蛋白1 (special AT-rich sequence binding protein,SATB1)的表达与大肠癌生物学行为的相关性。方法 采用免疫组织化学方法检测39例大肠癌及相应癌旁对照组织中SATB1蛋白的表达;并分析其与临床病理特征的关系。结果 SATB1蛋白在大肠癌组织中的表达水平与肿瘤浸润深度、TNM分期、淋巴结转移与远处转移有关(P<0.05)。结论 SATB1蛋白的表达水平增高可能与大肠癌的临床分期及其是否发生转移有关。更多还原

【Abstract】 Objective To detect the expression of special AT-rich sequence-binding protein(SATB1) in human colorectal cancer(CRC) and investigate its correlation to the biological behavior of the carcinoma.Methods Thritynine paired samples of CRC and distant normal rectal tissue were analyzed by immunohistochemistry(IHC),and the correlations between SATB1 expression and clinicopathological parameters were evaluated.Results SATB1 expression correlated with invasive depth,and tumor node metastasis(TNM) stage at protein level(P <0.05).Conclusion SATB1expression can be associated with the development and metastasis of CRC and may potentially serve as an indicator for predicting the prognosis of CRC.更多还原