【摘要】 目的观察地佐辛用于乳腺癌根治术后的静脉镇痛效果。方法选择60例拟全麻下行乳腺癌根治手术的患者,ASAⅠ、Ⅱ级,随机分为吗啡组(M组)和地佐辛组(D组),每组30例。术毕开始术后镇痛,持续48 h。分别于麻醉前、术毕及术后1、3、24 h采血,应用放射免疫分析法检测血清β-内啡肽(β-EP)。结果两组患者镇痛评分(VAS)、β-EP水平差异均无统计学意义(P>0.05)。结论吗啡和地佐辛均可有效抑制术后应激反应,镇痛效果确切,适合用于术后镇痛。更多还原

【Abstract】 Objective To observe the effects of intravenous analgesia with dezocine and morphine in patients with radical mastectomy of breast cancer.Methods A total of 60 patients undergoing radical mastectomy of breast cancer(ASAⅠ-Ⅱ) were recruited and divided into morphine group(group M,n=30) and dezocine group(group D,n=30).Patient controlled intravenous analgesia(PICA) lasted for 48 h.Peripheral venous blood was drawn before induction and at 1,3,24 h after operation.Serum levels of β-EP were measured with radioimmunoassay.Results There was no significant statistical significance among the two groups in visual analog scale(VAS) and the serum levels of β-EP(P>0.05).Conclusion Morphine and dezocine can inhibit the stress response and analgesia effectively.更多还原