【摘要】 目的:探讨新一代二磷酸盐唑来膦酸与常用药伊班膦酸钠对老年男性骨质疏松患者骨代谢指标影响的差异。方法:60例老年男性骨质疏松患者在每日给予钙尔奇D 0.6 g和骨化三醇胶丸0.25μg的治疗基础上,均静脉滴注2 mg伊班膦酸钠1次。3个月后将患者随机分为两组,一组仍静脉滴注伊班膦酸钠2 mg,另一组静脉滴注5 mg唑来膦酸。于治疗3个月后比较两组患者治疗前后及治疗后两组间甲状旁腺激素、β-胶原分解片段、降钙素、骨钙素、血清磷、血清钙差异。结果:①两组治疗后甲状旁腺激素、β-胶原分解片段均较治疗前下降(P<0.05),降钙素、骨钙素、血清磷、血清钙则无明显差异。②治疗后唑来膦酸组甲状旁腺激素、β-胶原分解片段较伊班膦酸钠组低(P<0.05);血钙也较伊班膦酸钠组低,但比较差异无统计学意义。结论:与伊班膦酸钠比较,静脉应用唑来膦酸对老年男性骨质疏松患者的甲状旁腺激素、β-胶原分解片段可能具更强的短期抑制作用。更多还原

【Abstract】 Objective: To investigate the differences of bone metabolism index in elderly male patients with osteoporosis,who were treated by intravenous Zoledronic acid,a new generation bisphosphonate,and Ibandronate.Method: Sixty elderly male patients with osteoporosis were enrolled.After the treatment of calcium carbonate-D 0.6 g/d and calcitriol capsules 0.25 μg/d,all patients were given 2 mg Ibandronate intravenous infusion once a month,then blood was collected.After three months,all patients were divided into two groups.Ibandronate Group was still given 2 mg intravenous infusion,and Zoledronic acid Group 5 mg was given intravenous Zoledronic acid treatment.Three months later,blood samples were collected again.Levels of parathyroid hormone,collagen degradation β-fragment,calcitonin,osteocalcin,serum phosphorus and serum calcium of the two groups before and after treatment were compared.Result: ①After treatment,levels of parathyroid hormone and β-decomposition of collagen fragments decreased significantly when compared with those before treatment(P<0.05),while levels of calcitonin,osteocalcin,serum phosphorus and serum calcium showed no significant difference before and after treatment.② After treatment,the levels of parathyroid hormone and β-decomposition of collagen fragments were significant lower in Zoledronic acid Group when compared to Ibandronate Group(P<0.05).The level of calcium was lower in Zoledronic acid Group too,but showed no statistical significance.Conclusion: In short-term,intravenous Zoledronic acid may strongly suppress levels of parathyroid hormone and β-fragment in elderly male with osteoporosis comparing to Ibandronate.更多还原