【摘要】 目的:研究复方红景天制剂对小鼠耐缺氧作用的影响。方法:通过常压密闭缺氧实验、亚硝酸钠中毒缺氧实验和急性脑缺血性缺氧3次实验,观察复方红景天制剂对缺氧小鼠的保护作用。每次实验用ICR小鼠40只,随机分为阴性对照组和复方红景天制剂低、中、高剂量组,检测各组小鼠缺氧存活平均时间。结果:与阴性对照组比较,复方红景天制剂不同剂量组均可明显延长小鼠常压缺氧和亚硝酸钠中毒情况下的存活时间(P<0.05或P<0.01);低剂量组对急性脑缺血性缺氧存活时间无显著性差异(P>0.05),中、高剂量组可明显延长急性脑缺血性缺氧情况下的存活时间(P<0.05)。结论:复方红景天制剂能有效地提高小鼠耐缺氧的能力。更多还原

【Abstract】 Objective To study of the hypoxic tolerance effect of compound rhodiola mixure in Mice.Methods The effects of compound rhodiola mixure on hypoxia tolerance in mice were measured through three kinds of experiments: the closed normobaric hypoxia mice ex periment,NaNO2poisoning-hypoxia experiment and acute cerebral ischemic-hypoxico experiment.Forty mice were used in each experi ment,and mice were randomly divided 4 groups: bland control group;low dose group,middle dose group and high dose group,and com pared the average survival time of each group.Results Compared with blank control group,three dose of compound rhodiola mixure could obviously improve the survival time of mice with the closed normobaric hypoxia and NaNO2 poisoning-hypoxia experiment(P< 0.05 orP<0.01).Low dose of compound rhodiola mixure could not obviously improve the survival time of mice with acute cerebral isch emic(P>0.05);but middle and high dose groups could obviously improve the survival time of mice with acute cerebral ischemic(P< 0.05).Conclusion Compound rhodiola mixure can effectively improve the ability of hypoxia tolerance of mice.更多还原