【摘要】 目的探讨术前不同治疗方法对局部晚期宫颈癌的疗效及预后的影响。方法回顾性分析35例Ⅰb2~Ⅱb2期术前新辅助化疗(NACT组)、33例术前放疗(RT组)和32例单纯手术(手术组)的局部晚期宫颈癌患者的临床资料,评价NACT组、RT组患者的近期疗效,并比较三组患者术中出血量、手术时间及术后病理特征。结果 NACT组总有效率为62.86%(22/35),RT组为57.58%(19/33)。三组患者手术时间、术中出血量、脉管受侵及阴道切缘癌残留率比较,差异无统计学意义(P>0.05),NACT组宫旁浸润率及淋巴结转移率低于手术组,差异有统计学意义(P<0.05),RT组宫旁浸润率低于手术组,差异有统计学意义(P<0.05),NACT组与RT组各项指标比较,差异均无统计学意义(P>0.05)。结论术前NACT、RT能缩小局部肿瘤,使宫旁浸润消退,可提高局部晚期宫颈癌的疗效。更多还原

【Abstract】 Objective To investigate the therapeutic effect of different preoperative treatment methods on the patients with locally advanced cervical carcinoma and their influence on prognosis.Methods The retrospective analysis was performed on the clinical data in 35 patients with stage Ⅰb2-Ⅱb2 treated by preoperative NACT,33 cases of locally advanced cervical carcinoma treated by preoperative radiotherapy(RT),32 cases of locally advanced cervical carcinoma treated by simple surgery.The short term effect of NACT and RT were assessed,the intraoperative blood loss,operation time and postoperative pathological characteristics were compared among three groups.Results The total effective rate was 62.86%(22/35) in the NACT group and 57.58%(19/33) in the RT group,respectively.There were no statistical differences in the surgery time,blood loss,lymphatic vascular invasion and the residual rate of vaginal cutting margin cancer among three groups.The parametrial infiltration rate and the lymph node metastasis rate in the NACT group were lower than those in the surgery group(P<0.05).There was significant difference between parametrial positive rate in RT and surgery(P<0.05).Various indexes had no statistical difference between There the NACT group and the RT group(P>0.05).Conclusion Preoperative NACT and preoperative RT can diminish the tumor size,decrease the parametrial infiltration and improve the short-term therapeutic effect in locally advanced cervical carcinoma.更多还原