【摘要】 目的探讨血清胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)与糖尿病周围神经神经病变(diabeticperipheral neuropathy,DPN)的关系。方法将58例2型糖尿病(T2DM)患者分为并发周围神经病变组(DPN组)及单纯T2DM(DM组),对照组为健康体检者(N组)。3组研究对象均测定空腹及糖负荷2 h血糖、血清GLP-1、C肽,同时测定糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)及血脂等生化指标。样本均数间比较采用t检验,指标间相关性采用Spear-man相关分析。结果 DM组患者血清GLP-1水平明显低于N组,合并DPN组低于无DPN组;血清GLP-1水平与血糖、HbA1c、三酰甘油(triacylglycerd,TG)、低密度脂蛋白胆固醇(low density lipophorin,LDL-C)水平呈负相关,而与C肽呈正相关。结论低血清GLP-1与T2DM周围神经病变密切相关,是其发病相关因素之一。更多还原

【Abstract】 Objective To investigate the relationship between serum glucagon-like peptide-1(GLP-1) and diabetic peripheral neuropathy(DPN).Methods 58 patient with T2DM were divided into the DPN and non-DPN groups.Fasting glucose and glucose of 2h post glucose-load,serum C-peptide and GLP-1,glycosylated hemoglobin and lipids were determined.The results were statistically analyzed.Results Serum GLP-1 in the DNP group was obviously increased compared with normal and non-DNP groups.Serum GLP-1 was negatively correlated to GLU,TG,LDL-C and HbAlc,whereas positively correlated to C-peptide.Conclusion Low serum GLP-1 is closely related to diabetic peripheral neuropathy and one of the risk factors for DPN.更多还原