【摘要】 组蛋白去乙酰化酶HDACs是调控基因的关键蛋白酶。基于生物信息学中的统计偶联分析方法,构建了统计偶联分析平台。基于该平台对HDACs进行了统计偶联分析。预测了HDAC8中关键氨基酸位点以及和H143偶联的氨基酸位点,有利于人们更深入地认识HDACs的结构和功能,为HDACs抑制剂的研究提供新的思路。更多还原

【Abstract】 Based on the theories and methods of bioinformatics, the statistical coupling analysis system was developed. Based on this system, the statistical coupling analysis was adopted to analyse histone deacetylases (HDACs),which play important roles in regulating gene expression. The key amino acids and those amino acids coupled with the H143 in HDAC8 were predicted. The results will be helpful not only to the understanding of the structure-function relationship of HDACs but also to the invention of novel HDACs inhibitors for the therapy of correlated diseases.更多还原