【摘要】 目的:探讨运动和血管紧张素转换酶抑制剂(培哚普利)干预对自发性高血压大鼠(SHR)血压、主动脉顺应性、心血管组织结构的影响。方法:38只7周龄SHR被分为对照组(C组,9只),运动组(Exe组,9只),培哚普利组(Per组,10只),培哚普利+运动组(Per+Exe组,10只),观察8周,每周用tail-cuff方法测定大鼠血压1次。15周龄时,用单回归分析各血压水平和主动脉的脉搏波传播速度(PWV)的关系得到回归直线(一次线性函数),我们用这个一次线性函数的斜率(b)作为主动脉顺应性的指标(b值和主动脉顺应性呈负相关关系)。用左心室重量/体重比(LVM/BW),主动脉重量/体重(AO/BW)比来评估心室、血管肥厚。结果:与C组比较,Exe组的收缩压(SBP)在12周龄(P<0.01)和13周龄(P<0.05)一度显著降低,14周龄时却无显著差异(P>0.05)。Per组和Per+Exe组的SBP在8周时即较C组显著降低(P<0.0001),两组比较无明显差异(P>0.05)。15周龄时,Per组和Per+Exe组的LVM/BW[(2.19±0.36)、(2.16±0.32)比(2.95±0.58)]、AO/BW[(0.20±0.01)、(0.19±0.01)比(0.26±0.01)]较C组明显降低(P均<0.05),但Per组和Per+Exe组间,C组与Exe组间没有显著差异(P>0.05)。各组的主动脉顺应性的指标b值分别为[C组:(21.2±1.2),Exe组:(20.5±1.4),Per组:(14.8±1.6),Per+Exe组:(15.0±1.3)],C组与Exe组间,Per组与Per+Exe组间均无显著差异(P>0.05)。结论:对于自发性高血压大鼠,8周运动有一定的降压趋势,但对于主动脉顺应性、心血管组织结构尚无显著影响。更多还原

【Abstract】 Objective:To explore influence of exercise training and angiotensin-converting enzyme inhibitor(perindopril) on blood pressure,aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats(SHR).Methods:A total of 38 SHR aged seven weeks were divided into control group(C group,n=9),exercise group(Exe group,n=9),perindopril group(Per group,n=10) and perindopril + exercise group(Per+Exe group,n=10).SHRs were observed for eight weeks,and tail-cuff method was used to measure systolic blood pressure(SBP)once a week.When rats were 15 weeks old,regression line(once linear function)was obtained by single regression analyzing the relation between blood pressure and pulse wave velocity(PWV).The b of this once linear function was used as index of aortic compliance(there was negative relationship between b and aortic compliance).The left ventricular mass(LVM)/body weight(BW)was used to evaluate ventricular thickening,and aortic weight(AO)/ BW was regard as index of vascular thickening.Results:Compared with C group,SBP of Exe group significantly decreased on 12 weeks old(P<0.01) and 13 weeks old(P<0.05),but decrease of SBP was no significant on 14 weeks old(P>0.05).SBP of Per group and Per+ Exe group on eight weeks old immediately decreased to level of seven weeks old(P<0.0001),but there was no significant difference between the two group(P>0.05).On 15 weeks old,the LVM/BW [(2.19±0.36) mg/g,(2.16±0.32) mg/g ] and AO/BW [(0.20±0.01) mg/g,(0.19±0.01) mg/g] of Per group and Per+ Exe group significantly decreased compared with C group [(2.95±0.58) mg/g,(0.26±0.01) mg/g],P<0.05 all,but there was no significant difference in these indexes between Per group and Per+ Exe group and between C group and Exe group(P>0.05 both).The b(index of aortic compliance)were [(C group :(21.2±1.2),Exe group:(20.5±1.4),Per group:(14.8±1.6),Per+Exe group:(15.0±1.3)] respectively,there was no significant difference between Per group and Per+ Exe group and between C group and Exe group(P>0.05 both).Conclusion:The exercise training of eight weeks possesses certain lowering blood pressure tendency,but no significant influence yet for aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats.更多还原