【摘要】 目的:探讨高血压患者血清肝细胞生长因子(HGF),可溶性细胞间黏附分子-1(sICAM-1)水平的变化及其意义。方法:选择59例高血压患者,其中高血压1级组20例,高血压2级组19例,高血压3级组20例,并选择30例健康体检者作为正常对照组。用酶联免疫双抗体夹心法检测各组血清HGF和sICAM-1浓度,并进行比较。结果:与正常对照组相比,高血压患者血清HGF[(641.65±142.90)pg/ml比(998.15±241.38)pg/ml]、sI-CAM-1[(161.70±32.36)ng/ml比(327.17±31.28)ng/ml]水平明显升高(P<0.01),血压越高,其变化越显著(P<0.01),HGF浓度与sICAM-1浓度呈正相关(r=0.317,P<0.01)。结论:HGF与sICAM-1可能参与了高血压的发病过程,而且HGF在高血压内皮细胞损伤的修复中可能具有重要作用。更多还原

【Abstract】 Objective : To study changes of serum levels of hepatocyte growth factor(HGF),soluble intercellular adhesion molecule-1(sICAM-1) in patients with essential hypertension(EH) and their significance.Methods : A total of 59 EH patients were selected,including 20 cases with EH stage 1(EH stage 1 group),19 cases with EH stage 2(EH stage 2 group) and 20 cases with EH stage 3(EH stage 3 group).Another 30 healthy subjects were regard as normal control group.Double antibody enzyme-linked immunosorbent sandwich assay was used to measure concentrations of HGF and sICAM-1 in all groups,and then the results were compared and analyzed.Results : Compared with normal control group,there were significant increase in serum levels of HGF [(641.65±142.90) pg / ml vs.(998.15±241.38) pg / ml ] and sICAM-1 [(161.70±32.36) ng / ml vs.(327.17±31.28) ng / ml ] in EH patients(P <0.01 both),and it′s more significant as blood pressure increased(P<0.01).HGF concentration was positively correlated with sICAM-1 concentration(r=0.317,P<0.01).Conclusion : HGF and sICAM-1 may participate in pathogenesis of hypertension,and HGF may play an important role in restore of impaired endothelial cells in hypertension.更多还原