【摘要】 目的:回顾性分析川崎病(KD)患儿合并脏器损害的临床类型及其高危因素。方法:采用回顾性调查方法,总结分析2005年1月至2010年10月120例住院KD患儿的临床资料,分析本病合并脏器损害的类型,同步分析脏器损害与年龄、热程、血生化指标及治疗时间等之间的关系。结果:KD脏器损害包括(1)心血管系统损害82例(68.3%),呼吸系统损害55例(45.83%),肝脏损害77例(64.2%),消化道异常18例(15.0%),泌尿系统异常15例(12.50%),血液系统异常主要表现在血小板升高133例(94.17%);(2)年龄<1岁,热程≥10d,血小板计数(PLT)≥300×109/L的KD患儿多脏器功能障碍的发生率明显高于年龄>1岁(85.0%比73.1%),热程<10d(87.8%比64.8%),PLT<300×109/L(79.0%比50.0%)的KD患儿,P均<0.05。结论:川崎病可以引起多脏器功能障碍。特别是在年龄<1岁,热程≥10d,PLT≥300×109/L的川崎病患儿,更要警惕多脏器功能障碍的发生。更多还原

【Abstract】 Objective:To retrospectively analyze clinical types and risk factors for children with Kawasaki disease(KD) complicated organ damage.Methods:Clinical data of 120 KD children admitted from Jan 2005 to Oct 2010 were retrospectively summarized and analyzed.Analyses were performed on types of organ damage complicated in KD,relationship among age,fever process,blood biochemical indexes,treatment duration and organ damage.Results:(1) Organ damages of KD included:cardiovascular system damage(n=82,68.3%),respiratory system damage(n=55,45.83%),liver damage(n=77,64.2%),gastrointestinal abnormalities(n=18,15.0%),urinary system abnormalities(n=15,12.50%),blood system abnormalities mainly manifesting platelet increase(n=133,94.17%);(2) Incidence rates of multi-organ dysfunction of KD children with age <one year old,fever process ≥10d and platelet counting(PLT) ≥300×109/L were significantly higher than those of KD children with age > one year old(85.0% vs.73.1%),fever process <10d(87.8% vs.64.8%) and PLT <300×109/L(79.0% vs.50.0%) respectively,P<0.05 all.Conclusion:Kawasaki disease can lead to multi-organ dysfunction,especially in children with Kawasaki disease with age <one year old,fever process ≥10d and platelet counting ≥300×109/L,for these patients should pay more attention to occurrence of multi-organ dysfunction.更多还原