【摘要】 目的:评价氯吡格雷对维、汉两族急性冠脉综合征患者的疗效和安全性。方法:入选2004年10月至2005年4月因急性冠脉综合征而住院的维吾尔族患者40例和汉族患者40例,氯吡格雷治疗12个月,观察两组出凝血时间、血小板计数的改变,主要不良心血管事件(心血管性死亡、心肌梗死、心肌缺血复发进行靶血管再通治疗)及出血事件的发生,评价其安全性。结果:两组均未发生主要不良心血管事件,两组各发生1例出血(维吾尔族组脑出血1例,汉族组消化道出血1例),无显著性差异(P>0.05),出、凝血时间均有不同程度的延长,但无显著性差异(P>0.05)。结论:维、汉两族急性冠脉综合征患者长期(12个月)使用氯吡格雷治疗安全、有效。更多还原

【Abstract】 Objective:To evaluate therapeutic effects and safety of clopidogrel in Uygur and Han nationality patients with acute coronary syndrome(ACS).Methods:A total of 40 Uygur nationality and 40 Han nationality ACS patients admitted from Oct 2004 to Apr 2005 were enrolled and received clopidogrel treatment for 12 months.Bleeding and clotting time,platelet counting,incidences of major adverse cardiovascular events(MACE,including cardiovascular death,myocardial infarction,target vessel revascularization for recurrence of myocardial ischemia) and hemorrhage were observed in the two groups,and safety of clopidogrel was evaluated.Results:No MACE occurred in two groups.One case of hemorrhage occurred in each group(one case with cerebral hemorrhage in Uygur nationality group,one case with gastrointestinal hemorrhage in Han nationality group),and there was no significant difference between the two groups(P>0.05).Bleeding and clotting time prolonged to some extent but were no significant difference in two groups(P>0.05).Conclusion:Clopidogrel treatment by long term(12 months) is safe and effective in Uygur and Han nationality patients with acute myocardial infarction.更多还原