【摘要】 目的观察小剂量紫杉醇(TAX)联合鬼臼乙叉甙(VP-16)、顺铂(DDP)治疗广泛期小细胞肺癌的临床疗效及毒副反应。方法将经病理学或细胞学检查确诊的广泛期小细胞肺癌患者69例随机分为治疗组32例与对照组37例,治疗组采用小剂量紫杉醇联合EP方案化疗(TAX100mg/m2静脉滴注,第1天;VP-16 100mg/m2静脉滴注,第1～3天;DDP 70mg/m2静脉滴注,第1天);对照组采用EP方案化疗,两组均每21天为1周期,每2个周期评价一次疗效,至少4周期。结果两组总有效率分别为71.88%(23/32例)和62.16%(23/37例),完全缓解率分别为12.5%(4/32例)和5.4%(2/37例),治疗组明显优于对照组,差异有显著性(P<0.05)。两组1、2年生存率分别为37.5%、15.62%和24.32%、5.4%,显示有差异趋势,但差异无显著性(P>0.05);治疗组中位生存期较对照组延长3.1个月,差异有显著性(P<0.05)。主要毒副反应是外周神经毒性、骨髓抑制、恶心呕吐及脱发。结论小剂量TAX联合EP方案化疗治疗广泛期小细胞肺癌有较好的近期疗效,1、2年生存率均有提高,毒副反应可耐受,可进一步推广研究。更多还原

【Abstract】 Objective To investigate the clinical efficacy and toxicity of combined chemotherapy with lower dose of TAX,VP-16 plus DDP in the treatment of patient with extensived small cell lung cancer(SCLC).Methods A total of 69 patients with SCLC were enrolled,32 in the trial group were assigned to receive TAX in combination with EP of chemotherapy and 37 in the control group to receive EP chemotherapy alone.TAX was administered 100mg/m2 on dl,VP-16 100mg/m2 on d1-35,DDP 70mg/m2 on d1 which was recycled every 3 or 4 weeks and with at least 4 cycles.Results Among the trial group,4 patients achieved complete response,11 patients achieved partial response,8 patients achieved stable disease and 9 patients achieved progressive disease.The overall response rate of the trial group is 71.88%(23/32).The 1-year and 2-year survival rates of the trial group were 37.5% and 15.62%.The main toxicities were neurotoxicity,myelosuppression,nausea/vomiting and alopecia.Conclusion Lower dose of TAX combine VP-16 plus DDP in treatment of SCLC has a good short-term effects,slight adverse reaction and a good tolerance,it is worthy of further study.更多还原