Epothilones are a new class of anticancer compounds produced by the Gram-negative myxobacterium Sorangium cellulosum.It shows high cytotoxicity for animal cells and mimic biological effect of taxol.In order to obtain epothilone producing strains,three pairs of primers were used to amplify fragments of epoA,epoC and epoK which encoding loading module,polyketide synthases(PKS) and P450 enzyme respectively in epothilone biosynthesis cluster from sixty S.cellulosum strains,and the PCR products were sequenced to...
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