【摘要】 目的观察20%甘露醇注射液改善晚期癌症生存质量的应用效果。方法选取200例晚期癌症患者作为研究对象,按照随机数字表法随机分为三组,即观察1组、观察2组、对照组,观察组均给予20%甘露醇注射液治疗,对照组常规治疗,治疗3个周期后比较三组患者止痛效果及生存质量水平。结果 (1)治疗3个周期后,观察1组CR+PR率为76.9%;观察2组CR+PR率为84.3%;对照组CR+PR率为36.9%。组间两两比较发现,观察1、2组均较对照组疼痛改善程度明显(P<0.05),观察1组较观察2组疼痛程度改善明显(P<0.05),具有统计学意义。(2)观察1、2组治疗3个周期后生活质量水平各项指标均较治疗前有所改善(P<0.05),对照组治疗后除认知功能外均有所改善;同时,观察1组较观察2组身体功能、情绪功能、认知功能、社会功能及总体健康状况具有显著差异(P<0.05),具有统计学意义。结论 20%甘露醇注射液可显著改善晚期癌症生存质量水平,且观察2组治疗方法更能减轻癌症疼痛及提高生活质量,可为临床治疗提供实践依据。更多还原

【Abstract】 Objective To observe the application effect of improving the survival quality with 20% mannitol injection during advanced cancer.Method 200 cases with advanced cancer receiving a treatment in Shunde Longjiang Hospital were selected as study objects.They were randomly divided into three groups(observation group 1,observation group 2 and control group)according to the method of random number table.20% mannitol injection was applied in two observation groups;conventional treatment was used for control group.After three cycles of treatment,the analgesic effect and the survival quality of patients in three groups were compared.Result First,after three cycles of treatment,the CR+PR rates of observation group 1,observation group 2 and control group were 76.9%,84.3% and 36.9%,respectively.After a comparison between any two groups,it was found that the pain of cases in observation groups 1 and 2 was more significantly improved than that in control group(P<0.05),and also the pain of cases in observation group 1 was more significantly improved than that of observation group 2(P<0.05),and these differences are of statistical significance.Second,all indexes of the survival qualities of observation groups 1 and 2 after three cycles of treatment were better improved than those before the treatment(P<0.05),and the functions of cases in control group were also improved except cognitive function.In the same time,the cases of observation group 1 were significantly different from the cases of observation group 2 in physical function,emotional function,cognitive function,social function and general health condition(P<0.05),and the difference was of statistical significance.Conclusion 20% mannitol injection can significantly help improve the survival quality of patients with advanced cancer,and the treatment method used in observation group 2 can more efficiently help patients reduce the pain and improve survival quality,thus it can provid a practice reference for clinical treatment.更多还原