【摘要】 目的研究唐山地区儿童感染性腹泻的病原菌变化、流行病学特征及耐药性变迁情况。方法对2008～2009年来某院就诊及住院患儿大便进行培养鉴定,采用纸片扩散法进行药敏试验。结果 890份粪便培养标本共检出病原菌86株,检出率为9.66%。其中沙门菌属28株(32.6%),致病性大肠杆菌17株(19.8%),志贺菌属14株(14.3%),奇异变形杆菌11株(12.8%),金黄色葡萄球菌8株(8.1%),小肠结肠炎耶尔森菌5株(5.8%),铜绿假单胞菌4株(4.7%);致病性大肠杆菌和志贺菌属对氨苄西林、头孢类抗生素的耐药性很高,呈多元耐药。沙门菌属明显低于志贺菌属,但有上升趋势;奇异变形杆菌的耐药性明显低于其他菌。金黄色葡萄球菌对大环内酯类药的耐药性很高。结论唐山地区儿童感染性腹泻的常见病原菌是沙门菌属、致病性大肠杆菌、志贺菌属、奇异变形杆菌和金黄色葡萄球菌。儿童感染性腹泻的治疗应根据药物的敏感性试验为依据。更多还原

【Abstract】 OBJECTIVE To investigate the etiology,epidemiologicfeatures,and drug-resistance tendency of acute infectious diarrhea among children in Tangshan area.METHODS 890 cases of stool samples were collected from outpatients and inpatients with diarrhea.Carried out bacterium isolation,cultivation and biochemical identification.Antibiotic susceptibility of bacteria was tested by disk diffusion method.RESULTS Of the 890 stool specimens,86 strains of pathogenic bacteria were detected with the detectable rate of 9.66%,28 of the 86 strains(32.6%) were Salmonella,17(19.8%) were pathogenic Escherichia coli,14(14.3%) were Shigella,11(12.8%) were Proteus mirabilis,8(8.1%) were Staphylococcus aureus,5(5.8%) were Yersinia enterocolitica,and 4 were Pseudomonas aeruginosa(4.7%).Pathogenic Escherichia coli and Shigella were resistant to ampicillin and cephalosporin antibiotic,showed multiple drug resistance.Salmonella was significantly lower than Shigella species,but there was an upward trend;Proteus mirabilis was lower than others.Staphylococcus aureus was high resistant to fluoroquinolones.CONCLUSION The main pathogenic bacteria which cause children’s bacterial diarrhea in Tangshan are Salmonella,pathogenic Escherichia coli,Shigella,Proteus mirabilis,Staphylococcus aureus,Yersinia enterocolitica and Pseudomonas.The treatment of infectious diarrhea of children should be based on drug susceptibility testing.更多还原