【摘要】 目的分析201例HIV-1感染者/AIDS病人体内的病毒载量水平的变化,预测疾病进展情况。方法检测201例经WB实验确证为阳性者体内的HIV病毒载量,并进行随访。结果未治疗感染者和接受治疗的艾滋病人之间病毒载量差异有统计学意义(t=6.492,P﹤0.05),41例病人治疗效果显著,72例病人病毒复制不同程度受到了药物的抑制作用,但是有40例病人病毒载量升高,最大升高了5.05个lg值,抗病毒治疗疗效低,甚至无效。结论大部分艾滋病人抗病毒药物治疗的效果明显,但随着治疗时间延长,部分病人的病毒数量回升,甚至超过了治疗前的病毒含量,这种情况的出现显示HIV基因可能产生了针对治疗药物的耐药突变。更多还原

【Abstract】 OBJECTIVE To evaluate disease processes by analyzing the variance of viral load in 201 HIV-1 infectors and AIDS patients accepted highly active antiretroviral therapy(HAART).METHODS The viral load of HIV was detected in 201 HIV-1 infectors and AIDS patients after highly active antiretroviral therapy,and then a follow-up investigation was carried out.RESULTS The viral load in AIDS patients had statistically significant differences between HIV-1 infectors and AIDS patients.Effectiveness of 41 patients were obvious,and the decline of 72 patients’viral load was observed,but 40 patients’ viral load went up,up to 5.05 lg at highest,which indicated low medicine effectiveness.CONCLUSION The effect of HAART is significant in most AIDS patients,but the level of viral load appears rebound phenomenon with the time of the therapy prolonging.It is obvious that HIV-1 might come about drug-resistance in view of antiviral drug.更多还原