【摘要】 目的观察张家口地区人群乙肝病毒基因型及其与肝病的相关性。方法采用巢式荧光实时定量PCR对107例乙肝病毒感染患者基因型进行检测;对患者肝病临床类型、血液乙肝病毒DNA定量、碱性磷酸酶、谷丙转氨酶、甲胎蛋白、谷氨酰转肽酶等指标进行观察与分析。结果①张家口地区乙肝患者乙肝病毒基因型主要以B型、C型与B+C混合型为主,107例患者中B型32例,C型30例,B+C混合型45例;②C型患者HBVDNA浓度、肝功能指标、甲胎蛋白、肝硬化发生率、肝癌发生率均显著高于B型及B+C混合型患者,且差异有统计学意义(P﹤0.05)。结论张家口地区乙肝患者病毒基因型以B型、C型及B+C混合型为主,C型患者肝硬化、肝癌的发生率以及肝功能损害程度明显高于B型及B+C混合型患者。更多还原

【Abstract】 OBJECTIVE To observe hepatitis B virus genotypes among Zhangjiakou area and its relationship with liver disease.METHODS Tested 107 genotypes of HBV infected cases with nested fluorescence real-time quantitative PCR;observed and analyzed indicators such as types of liver disease,blood HBV DNA quantitative,alkaline phosphatase,GPT,AFP,γ-GGT in patients with infected HBV.RESULTS ① Genotype B,C and B+C were the main genotypes of HBV in Zhangjiakou area,among 107 cases,32 were genotype B,30 were genotype C and 45 were genotype B+C;② blood HBV DNA quantitative,alkaline phosphatase,GPT,AFP in patients with genotype C were significantly higher than other two groups(P﹤0.05).CONCLUSION HBV genotypes in patients infected with HBV in Zhangjiakou area are mainly B,C and B+C types,incidences of cirrhosis,liver cancer and liver damage in patients with genotype C are significantly higher than type B and B+C hybrid.更多还原